More Than 20 Per Cent Weight Loss: 'Breakthrough' Obesity Drug Trial
US researchers are trumpeting a new drug as a "game changer" in the management of obesity - and for once, a large, gold-standard clinical trial backs up the hype. A single weekly injection of the drug semaglutide, for MedicGLP 68 weeks, saw an average loss of 15 percent body weight in trial participants. Those given a placebo, in tandem with a diet and exercise program, lost 2.4 per cent of their body weight. More than a third of the participants who took the drug lost more than 20 percent of their weight. As experts told the Times, these results far exceed the amount of weight loss observed in clinical trials of other obesity medications. The drug is a "game-changer," said Dr. Robert F. Kushner, an obesity researcher at Northwestern University Feinberg School of Medicine, who led the study. No long wait required. Semaglutide isn’t brand MedicGLP new. It was discovered in 2012 by researchers at Novo Nordisk, a Danish healthcare company with a focus on chronic disease.
Novo Nordisk funded the latest trial. The drug was approved in 2017 by the USFDA as an injectable type II diabetes treatment. The New Daily has found that, MedicGLP Capsules for the last four months, the drug has been prescribed off-label "for diabetic care and as a weight loss agent" by Western Australian bariatric surgeon, MedicGLP Dietary Supplement Dr Leon Cohen. Dr Leon Cohen, surgeon and director of Mercy Bariatrics in WA has been prescribing the new weight-loss drug for about four months. Dr Cohen said his patients had been getting similar results to that achieved in the clinical trial - but at a much lower dose. "The drug usually comes with a starting dose of 0.25mg and then you gradually build it up to 1mg," he said. In the new trial, participants - who had a BMI of 30 or more, and thus technically obese - were given 2.4mg as an anti-obesity medicine. Dr Cohen said the drug mimics GLP-1, a gut hormone that’s released in response to undigested food hitting the distal small bowel.
"It’s an interesting and exciting mechanism, because essentially what the body needs is a mechanism which can sense you’ve just had a large meal and there’s still a lot of undigested food that hasn’t been absorbed," he said. He said: "It doesn’t matter what treatment you give to someone with a low BMI, they get a good result. They only need to lose 10 kilos and you get a very respectable percentage of your weight loss. But most of his patients have a BMI over 40 and surgery remains their only viable option. Dr Cohen allowed that very few people who needed surgery could either afford it or were willing to take it up. It appears that for type II diabetics, or people edging into obesity, this new drug may be the game changer as touted by its makers. Side effects tend to be, in the main, mild gastrointestinal complaints. Long term effects at the higher dose are unknown. A1292) in the USA, Dr Cohen’s patients are charged $160 a month. He said for people with poorly controlled diabetes, with an authority script, the cost could be much lower. But once you’re on semaglutide, it’s probably for life. Trial participants rejoiced at their weight loss. But once they stopped taking the drug, the weight came back.
Science continues to prove that the old adage "you are what you eat" is profoundly true. This is because you have trillions of microorganisms living in your gut, which are directly responsible for nearly every aspect of your health. These microbes make up what’s called your "gut microbiota." They are especially influential in determining your likelihood of gaining excessive weight, becoming obese, and developing obesity-related diseases like diabetes, heart disease, and premature death. The gut microbiome (the expressed genes of your gut microbiota) plays a major role in your metabolism through energy production, storage, and expenditure. So, it’s no surprise that science has found a strong connection between gut microbiome imbalance and metabolic syndrome. Yikes! If you have the wrong mix of microbes, it could be making it tough for you to get your health on track! Did you know: Scientists can actually look at your gut microbiome composition and tell with 90% accuracy if you are obese or lean. That’s pretty impressive, isn’t it?
1. Unable to lose weight and keep it off? 2. Struggling to fight cravings? 3. Sick of starving yourself for weight loss? 4. Baffled as to why no diet seems to really work for you? Depending on the composition of your gut microbiome, your microbes can either boost your health or weigh you down (figuratively and literally). The good news is this: You have control over these little guys with every bite you eat. Diet has the power to change the landscape of your gut microbiome. So, if you’ve tried multiple diets and can’t seem to get the results you want, it’s time to look into your gut microbiome.Will You Lose Weight Naturally on an Individualized Diet? If you’ve been struggling to lose weight and keep it off - it could be your gut microbiome. While Viome doesn’t guarantee weight loss, it has been an exciting result many of our customers have reported. "Fiona’s update day 37!